Article

Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes

2025-05-12

Abstract excerpt

<h4>SUMMARY</h4> Chromosomal instability (CIN) is a hallmark of prostate cancer that strongly correlates with metastatic burden and appears prominently in both primary cancer and metastatic disease. Low Gleason score primary prostate tumors display pervasive centrosome loss, a known mechanistic driver of CIN, that disrupts normal spindle assembly and increases mitotic errors. Previously, we found that transient d...

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Literature Corpus work: bb77933a-3963-53df-a8ed-4f6191c029ee
DOI: 10.1101/2025.05.10.653266

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