Article

The Icelandic mutation APP <sup>A673T</sup> on amyloid-β plaque burden in the 5xFAD Alzheimer model

2025-11-06

Abstract excerpt

The protective Icelandic mutation in the amyloid precursor protein (APP) gene, APP A673T , identified in Icelandic and other Nordic populations is associated with a significantly lower risk of developing Alzheimer’s disease (AD). Conflicting results have been reported for the APP A673T mutation in various knock-in models of AD, but its effect in 5x familial AD (5xFAD) mice has never been investigated. We have cr...

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Literature Corpus work: de431e3a-4a8f-55bd-8c3f-29025a48c70a
DOI: 10.1101/2025.11.05.686739

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