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New <i>App</i> knock-in mice that accumulate wild-type human Aβ as rapidly as <i> App <sup>NL-G-F</sup> </i> mice exhibit intensive cored plaque pathology and neuroinflammation

2021-04-30

Abstract excerpt

We previously developed single App knock-in mouse models of Alzheimer’s disease (AD), harboring the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation ( App NL-G-F and App NL-F mice). These models showed amyloid β peptide (Aβ) pathology, neuroinflammation and cognitive impairment in an age-dependent manner. The former line exhibits extensive pathology as early as 6 months but is unsu...

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Literature Corpus work
2c43a9dc-a1e3-542f-9f1b-13eb82fbf76e
DOI
10.1101/2021.04.30.442122
Open publication

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New <i>App</i> knock-in mice that accumulate wild-type human Aβ as rapidly as <i> App <sup>NL-G-F</sup> </i> mice exhibit intensive cored plaque pathology and neuroinflammationDOI 10.1101/2021.04.30.442122
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