A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

doi:10.1038/nature11283

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Article

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

Nature - 2 Aug 2012

Jonsson Thorlakur, Atwal Jasvinder K, Steinberg Stacy, Snaedal Jon, Jonsson Palmi V, Bjornsson Sigurbjorn, Stefansson Hreinn, Sulem Patrick, Gudbjartsson Daniel, Maloney Janice, Hoyte Kwame, Gustafson Amy, Liu Yichin, Lu Yanmei, Bhangale Tushar, Graham Robert R, Huttenlocher Johanna, Bjornsdottir Gyda, Andreassen Ole A, Jönsson Erik G, Palotie Aarno, Behrens Timothy W, Magnusson Olafur T, Kong Augustine, Thorsteinsdottir Unnur, Watts Ryan J, Stefansson Kari

Abstract excerpt

The prevalence of dementia in the Western world in people over the age of 60 has been estimated to be greater than 5%, about two-thirds of which are due to Alzheimer's disease. The age-specific prevalence of Alzheimer's disease nearly doubles every 5 years after age 65, leading to a prevalence of greater than 25% in those over the age of 90 (ref. 3). Here, to search for low-frequency variants in the amyloid-β...

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PMID: 22801501
DOI: 10.1038/nature11283

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