Article

The Protective A673T mutation of Amyloid precursor protein (APP) in Alzheimer’s disease

2021-02-01

Abstract excerpt

<title>Abstract</title> <p>Alzheimer's Disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides, and neurofibrillary tangles consisted of intracellular hyperphosphorylated Tau in the hippocampus and cerebral cortex. Most of the mutations in key genes that code for amyloid precursor protein can lead to significant accumulation of these peptides in the brain and cause...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5ee9dc4-d05d-51de-8fe2-25e531c564cb
DOI: 10.21203/rs.3.rs-169514/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Protective A673T mutation of Amyloid precursor protein (APP) in Alzheimer’s diseaseDOI 10.21203/rs.3.rs-169514/v1Read

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s DiseaseSemantic proximity Read

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.Semantic proximity Read

APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance.Semantic proximity Read

Good gene, bad gene: new APP variant may be both.Semantic proximity Read

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.Semantic proximity Read

Protective Alzheimer’s disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture modelsSemantic proximity Read

Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine.Semantic proximity Read

E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's diseaseSemantic proximity Read

Identification of a novel mutation in APP gene in a Thai subject with early-onset Alzheimer's diseaseSemantic proximity Read

Mutations in APP and their role in beta-amyloid deposition.Semantic proximity Read

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.Semantic proximity Read

Amyloid β-peptide and Alzheimer's disease.Semantic proximity Read