Article

The effect of the Icelandic mutation APP <sup>A673T</sup> in the line 66 model of tauopathy

2025-10-10

Abstract excerpt

The Icelandic mutation in the amyloid precursor protein (APP), APP A673T , has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer’s disease (AD). Although this mutation led to reduction in amyloid β-protein (Aβ) production, its effect on tau pathology is not well studied. We have crossed line 66 (L66) tau transgenic mice that overexp...

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Literature Corpus work: 023d215e-28bd-5342-a997-82903c6ec741
DOI: 10.1101/2025.10.09.681356

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