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Article

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation.

eLife - 5 Feb 2020

Tambini Marc D, Norris Kelly A, D'Adamio Luciano

Abstract excerpt

Cleavage of APP by BACE1/β-secretase initiates the amyloidogenic cascade leading to Amyloid-β (Aβ) production. α-Secretase initiates the non-amyloidogenic pathway preventing Aβ production. Several APP mutations cause familial Alzheimer's disease (AD), while the Icelandic APP mutation near the BACE1-cleavage site protects from sporadic dementia, emphasizing APP's role in dementia pathogenesis. To study APP...

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Identifiers

PMID: 32022689
DOI: 10.7554/eLife.52612
PMCID: PMC7018507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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