Article
Effect of the Icelandic Mutation APPA673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice.
Biomolecules - 24 Dec 2025
Anschuetz Anne, Robinson Lianne, Mondesir Miguel, Melis Valeria, Platt Bettina, Harrington Charles R, Riedel Gernot, Schwab Karima
Abstract excerpt
The Icelandic mutation in the amyloid precursor protein (APP), APPA673T, has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer's disease (AD). The introduction of the human APPA673T form led to a reduction in amyloid β-protein (Aβ) production and tau pathology, but the effect of mouse APPA673T on tau and Aβ pathology is not well...
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