Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model.

Journal of integrative neuroscience - 22 Jan 2026

Anschuetz Anne, Listyono Renny, Vorley Thomas, Platt Bettina, Harrington Charles R, Riedel Gernot, Schwab Karima

Abstract excerpt

BACKGROUND: The protective Icelandic mutation in the amyloid precursor protein (APP) gene, APPA673T, identified in Icelandic and other Nordic populations is associated with a significantly lower risk of developing Alzheimer's disease (AD). Conflicting results have been reported for the human APPA673T mutation in various knock-in models of AD, but the effect of the mouse APPA673T form in 5× familial AD (5×FAD)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Plaque, Amyloid

Share to Presenilin-1

Source

Identifiers

PMID: 41609044
DOI: 10.31083/JIN48581

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model.PMID 41609044Read ↗

The Icelandic mutation APP <sup>A673T</sup> on amyloid-β plaque burden in the 5xFAD Alzheimer modelSemantic proximity Read ↗

Effect of the Icelandic Mutation APPA673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice.Semantic proximity Read ↗

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.Semantic proximity Read ↗

The effect of the Icelandic mutation APP <sup>A673T</sup> in the line 66 model of tauopathySemantic proximity Read ↗

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.Semantic proximity Read ↗

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss.Semantic proximity Read ↗

Single App knock-in mouse models of Alzheimer's disease.Semantic proximity Read ↗

New <i>App</i> knock-in mice that accumulate wild-type human Aβ as rapidly as <i> App <sup>NL-G-F</sup> </i> mice exhibit intensive cored plaque pathology and neuroinflammationSemantic proximity Read ↗

An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo.Semantic proximity Read ↗

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitroSemantic proximity Read ↗

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation.Semantic proximity Read ↗

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.