Article

Protective mutation A673T as a potential gene therapy for most forms of APP Familial Alzheimer’s Disease

2020-07-22

Abstract excerpt

The accumulation of plaque in the brain leads to the onset and development of Alzheimer’s disease. The Amyloid precursor protein (APP) is usually cut by α-secretase, however an abnormal cleavage profile by β-secretase (BACE1) leads to the accumulation of Aβ peptides, which forms these plaques. Numerous APP gene mutations favor plaque accumulation, causing Familial Alzheimer Disease (FAD). However, a variant of the...

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Literature Corpus work: c751ab9f-477e-54a8-b7c0-98417f7a463f
DOI: 10.1101/2020.07.22.215616

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