Article

Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization

2026-01-29

Abstract excerpt

Polygenic scores (PGS) summarize the combined effects of common single-nucleotide polymorphisms and contribute to predictions of disease severity, but biological consequences linked to these common variants remain poorly defined. Here, we focused on polygenic liability for a measurable electrophysiologic trait (the QT interval). Prolonged QT interval, measured on patient electrocardiograms, is associated with an i...

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Literature Corpus work: ddf58168-f469-57cb-bda3-0ed0a00c1d8e
DOI: 10.64898/2026.01.27.701872

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Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac RepolarizationDOI 10.64898/2026.01.27.701872Read

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