Article
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.
Circulation. Genomic and precision medicine - 1 Jan 2018
Bihlmeyer Nathan A, Brody Jennifer A, Smith Albert Vernon, Warren Helen R, Lin Honghuang, Isaacs Aaron, Liu Ching-Ti, Marten Jonathan, Radmanesh Farid, Hall Leanne M, Grarup Niels, Mei Hao, Müller-Nurasyid Martina, Huffman Jennifer E, Verweij Niek, Guo Xiuqing, Yao Jie, Li-Gao Ruifang, van den Berg Marten, Weiss Stefan, Prins Bram P, van Setten Jessica, Haessler Jeffrey, Lyytikäinen Leo-Pekka, Li Man, Alonso Alvaro, Soliman Elsayed Z, Bis Joshua C, Austin Tom, Chen Yii-Der Ida, Psaty Bruce M, Harrris Tamara B, Launer Lenore J, Padmanabhan Sandosh, Dominiczak Anna, Huang Paul L, Xie Zhijun, Ellinor Patrick T, Kors Jan A, Campbell Archie, Murray Alison D, Nelson Christopher P, Tobin Martin D, Bork-Jensen Jette, Hansen Torben, Pedersen Oluf, Linneberg Allan, Sinner Moritz F, Peters Annette, Waldenberger Melanie, Meitinger Thomas, Perz Siegfried, Kolcic Ivana, Rudan Igor, de Boer Rudolf A, van der Meer Peter, Lin Henry J, Taylor Kent D, de Mutsert Renée, Trompet Stella, Jukema J Wouter, Maan Arie C, Stricker Bruno H C, Rivadeneira Fernando, Uitterlinden André, Völker Uwe, Homuth Georg, Völzke Henry, Felix Stephan B, Mangino Massimo, Spector Timothy D, Bots Michiel L, Perez Marco, Raitakari Olli T, Kähönen Mika, Mononen Nina, Gudnason Vilmundur, Munroe Patricia B, Lubitz Steven A, van Duijn Cornelia M, Newton-Cheh Christopher H, Hayward Caroline, Rosand Jonathan, Samani Nilesh J, Kanters Jørgen K, Wilson James G, Kääb Stefan, Polasek Ozren, van der Harst Pim, Heckbert Susan R, Rotter Jerome I, Mook-Kanamori Dennis O, Eijgelsheim Mark, Dörr Marcus, Jamshidi Yalda, Asselbergs Folkert W, Kooperberg Charles, Lehtimäki Terho, Arking Dan E, Sotoodehnia Nona
Abstract excerpt
BACKGROUND: QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest. METHODS AND RESULTS: We performed an ExomeChip-wide analysis for both QT and JT intervals,...
