From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi-Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death.

Abstract excerpt

QT prolongation causes torsades de pointes sudden death from heritable, pharmacologic, metabolic, nutritional triggers. Its dimensions have been studied separately. This integrative review synthesizes research on molecular pathogenesis, acquired/metabolic/nutritional risks, clinical stratification, therapy, and AI prediction. Dual-function channel mutations and post-translational defects underlie congenital LQTS...

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