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Article

A combined genomic arrhythmia propensity score delineates cumulative risk.

Cell reports. Medicine - 18 Nov 2025

Monroe Tanner O, Puckelwartz Megan J, Pesce Lorenzo L, Kearns Samuel D, Page Patrick, Ibrahim Nora, Weber Zachary T, Ugwor Emmanuel I, Nóbrega Marcelo A, Kannankeril Prince, Rasmussen-Torvik Laura J, Dellefave-Castillo Lisa M, George Alfred L, Webster Gregory, McNally Elizabeth M

Abstract excerpt

Cardiac ventricular arrhythmias can cause sudden death. Despite known genomic contributions, multigenic risk predictors are limited. The genetics of arrhythmias and cardiomyopathies overlap, with additional overlap with epilepsy. To improve genetic risk prediction, we assemble a cohort with non-ischemic ventricular arrhythmias and controls lacking cardiac diagnoses. Here, we integrate 18 polygenic scores;...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41223854
DOI: 10.1016/j.xcrm.2025.102455
PMCID: PMC12711699

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