Article

MeTAL enables multiparametric risk prediction for human <i>KCNH2</i> variants

2026-05-04

Abstract excerpt

<h4>Background</h4> Clinical interpretation of missense variants in the hERG potassium channel encoded by the KCNH2 gene remains a major challenge in inherited arrhythmia syndromes. Functional studies often rely on a minimal set of channel properties, mainly current amplitude measurements, which do not capture the multidimensional nature of channel gating and its impact on ventricular repolarization. We develope...

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Literature Corpus work: fd0b4284-1f0b-5d9c-9852-93b8a28791e2
DOI: 10.64898/2026.04.29.721778

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