Article

Patient-derived Cellular Models of Polygenic Scores: Application to Long QT Syndrome

2025-08-07

Abstract excerpt

Polygenic scores (PGS) have emerged as important modifiers of disease risk, drug response, and rare variant penetrance, but the biological mechanisms underlying these associations remain poorly understood. To experimentally investigate these relationships, we derived induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from individuals at the 1st, 50th, and 99th percentiles of a genome-wide QT interval...

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Literature Corpus work: 8eeda598-7176-5f5e-8dfc-a62b478752f8
DOI: 10.1101/2025.08.05.667271

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