Article

Cytosolic and ER-associated ribosomes share rRNA 2′-O-methylation landscapes across human cell types

2026-03-28

Abstract excerpt

Ribosome heterogeneity arising from variable rRNA 2′O-methylation (2′O-Me) has been proposed as a potential mechanism for translational specialization, but whether such heterogeneity contributes to compartment-specific translation remains unknown. Here, we systematically compare the 2′O-Me landscapes of cytosolic and endoplasmic reticulum (ER)–associated ribosomes across three human cell types: HEK293 cells, H9-de...

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Literature Corpus work: ddf43bde-95ed-550c-bb8b-dafa1087e4b8
DOI: 10.64898/2026.03.26.714425

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