Article

Cellular senescence and quiescence are associated with altered ribosomal RNA methylation and processing

2020-04-02

Abstract excerpt

The 2’-O-methylation (2’-O-Me) of ribosomal RNA (rRNA) shows plasticity potentially associated with specific cell phenotypes. We used RiboMeth-seq profiling to reveal 2’-O-Me patterns specific to stress induced premature senescent (SIPS), quiescent and proliferating human dermal fibroblasts. The altered methylation levels in SIPS and quiescence partially correlated with the expression of specific snoRNAs but not f...

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Literature Corpus work: b370ff70-1730-5827-8609-dccd618b6b6e
DOI: 10.1101/2020.04.01.019653

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