Article

Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRP

2024-07-25

Abstract excerpt

The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an Autism Spectrum Disorder. FMRP interacts with ribosomes and regulates the translation of mRNAs essential for neuronal development and synaptic plasticity. However, the biochemical nature of this translation regulation is unknow...

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Literature Corpus work: 46696bf3-6e32-59d8-8b69-c1e0a6b2188f
DOI: 10.1101/2024.07.25.605157

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