Article

Leveraging Family History in Case-Control Analyses of Rare Variation

2019-06-09

Abstract excerpt

Standard methods for case-control association studies of rare variation often treat disease outcome as a dichotomous phenotype. However, both theoretical and experimental studies have demonstrated that subjects with a family history of disease can be enriched for risk variation relative to subjects without such history. Assuming family history information is available, this observation motivates the idea of replac...

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Literature Corpus work: ddb83e9b-6aab-56bf-ac72-dad1bf0ef86d
DOI: 10.1101/665075

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