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Article

Assessing disease risk in genome-wide association studies using family history.

Epidemiology (Cambridge, Mass.) - 1 Jul 2012

Ghosh Arpita, Hartge Patricia, Purdue Mark P, Chanock Stephen J, Amundadottir Laufey, Wang Zhaoming, Wentzensen Nicolas, Chatterjee Nilanjan, Wacholder Sholom

Abstract excerpt

We show how to use reports of cancer in family members to discover additional genetic associations or confirm previous findings in genome-wide association (GWA) studies conducted in case-control, cohort, or cross-sectional studies. Our novel family history-based approach allows economical association studies for multiple cancers, without genotyping of relatives (as required in family studies), follow-up of...

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Identifiers

PMID: 22575968
DOI: 10.1097/EDE.0b013e31825583a0
PMCID: PMC3371359

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Source receipt: pubmed, retrieved 7 Sept 2026.

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