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Article

Comparison of family history and SNPs for predicting risk of complex disease.

PLoS genetics - 1 Jan 2012

Do Chuong B, Hinds David A, Francke Uta, Eriksson Nicholas

Abstract excerpt

The clinical utility of family history and genetic tests is generally well understood for simple Mendelian disorders and rare subforms of complex diseases that are directly attributable to highly penetrant genetic variants. However, little is presently known regarding the performance of these methods in situations where disease susceptibility depends on the cumulative contribution of multiple genetic factors of...

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PMID: 23071447
DOI: 10.1371/journal.pgen.1002973
PMCID: PMC3469463

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