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Article

Liability threshold modeling of case-control status and family history of disease increases association power.

Nature genetics - 1 May 2020

Hujoel Margaux L A, Gazal Steven, Loh Po-Ru, Patterson Nick, Price Alkes L

Abstract excerpt

Family history of disease can provide valuable information in case-control association studies, but it is currently unclear how to best combine case-control status and family history of disease. We developed an association method based on posterior mean genetic liabilities under a liability threshold model, conditional on case-control status and family history (LT-FH). Analyzing 12 diseases from the UK Biobank...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32313248
DOI: 10.1038/s41588-020-0613-6
PMCID: PMC7210076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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