Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PHOX2B Immunolocalization of the Candidate Human Retrotrapezoid Nucleus

5 Nov 2009

Abstract excerpt

Research in animal models implicates the retrotrapezoid nucleus (RTN) as a critical central chemoreceptor located in the brain stem. In rodents, RTN neurons co-express the tachykinin receptor NK1R and the transcription factor PHOX2B. In humans, PHOX2B mutations, which expand a polyalanine tract in the protein, cause congenital central hypoventilation syndrome. Mice with analogous Phox2B mutations model this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal Respiratory Health Research
Share to Neuroendocrine regulation and behavior
Share to Neuroscience of respiration and sleep

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19888871
DOI: 10.2350/09-07-0682-oa.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PHOX2B Immunolocalization of the Candidate Human Retrotrapezoid NucleusPMID 19888871Read ↗

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.Semantic proximity Read ↗

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO <sub>2</sub> chemoreflex in ratsSemantic proximity Read ↗

Respiratory and autonomic dysfunction in congenital central hypoventilation syndromeSemantic proximity Read ↗

Expression of Phox2b by Brainstem Neurons Involved in Chemosensory Integration in the Adult RatSemantic proximity Read ↗

Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.Semantic proximity Read ↗

<i>Phox2b</i> mutation mediated by <i>Atoh1</i> expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapniaSemantic proximity Read ↗

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.Semantic proximity Read ↗

Breathing with phox2b.Semantic proximity Read ↗

Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia.Semantic proximity Read ↗

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.Semantic proximity Read ↗

PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas.Semantic proximity Read ↗

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and HumansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.