Article

Combined Checkpoint Inhibition Amplifies Post-Infarction Injury via T Cell-Mediated Macrophage Activation

2026-05-21

Abstract excerpt

<h4>Background</h4> This study aimed to investigate whether combined PD-1/CTLA-4 immune checkpoint inhibition predisposes the heart to a hyperinflammatory state, thereby exacerbating cardiac injury following acute myocardial infarction (MI), a critical unresolved question in cardio-oncology. <h4>Methods</h4> Myocardial infarction was induced in Pd1 −/− Ctla4 +/− mice, a genetic model mimicking combined checkpoi...

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Literature Corpus work: f61edeba-fba5-535c-9afc-d2ad6090cbee
DOI: 10.64898/2026.05.18.726115

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