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Article

Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients.

Journal of molecular and cellular cardiology - 1 Mar 2026

Angelotti Austin, Ponnusamy Thiruvelselvan, Kumar Vinay, Passarelli Gianna V, Malysz Jozef, Mahesh Balakrishnan, Soleimani Behzad, Bradley Elisa A, Bansal Shyam S

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) is characterized by increased infiltration and activation of the innate immune system, including neutrophils, monocytes/macrophages, and dendritic cells. However, the phenotypic profile of cardiac CD3+ T-cells and its CD4+ and CD8+ subsets have not been characterized in DCM patients. METHODS: We studied phenotypic signatures of T-cell subsets by analyzing publicly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41453508
DOI: 10.1016/j.yjmcc.2025.12.011
PMCID: PMC12908628

Genes

CD4
CCR7
MAL
SELL
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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