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CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2 <sup>+</sup> macrophages and CD8 T-cells

2024-03-16

Abstract excerpt

Novel immune checkpoint therapeutics including CD40 agonists have tremendous promise to elicit antitumor responses in patients resistant to current therapies. Conventional immune checkpoint inhibitors (PD-1/PD-L1, CTLA-4 antagonists) are associated with serious adverse cardiac events including life-threatening myocarditis. However, little is known regarding the potential for CD40 agonists to trigger myocardial inf...

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Identifiers and source

Literature Corpus work
916556f8-5111-5355-8786-55feee813716
DOI
10.1101/2024.03.14.584418
Open publication

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CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2 <sup>+</sup> macrophages and CD8 T-cellsDOI 10.1101/2024.03.14.584418
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