Article
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.
Circulation. Heart failure - 1 Mar 2017
Bansal Shyam S, Ismahil Mohamed Ameen, Goel Mehak, Patel Bindiya, Hamid Tariq, Rokosh Gregg, Prabhu Sumanth D
Abstract excerpt
BACKGROUND: Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear. METHODS AND RESULTS: Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant (P<0.05) expansion of...
Topics
- Adoptive Transfer
- Animals
- Cell Proliferation
- Cytokines
- Disease Models, Animal
- Heart Failure
- Immunologic Memory
- Lymph Nodes
- Lymphocyte Activation
- Male
- Mice, Inbred C57BL
- Myocardial Ischemia
- Myocardium
- Phenotype