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Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis

11 Jan 2019

Abstract excerpt

Cardiac fibroblasts are the major producers of extracellular matrix (ECM) to form infarct scar. We hypothesized that fibroblasts undergo a spectrum of phenotype states over the course of myocardial infarction (MI) from early onset to scar formation. Fibroblasts were isolated from the infarct region of C57BL/6J male mice (3-6 months old, n = 60) at days 0 (no MI control) and 1, 3, or 7 after MI. Whole...

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PMID: 30635789
DOI: 10.1007/s00395-019-0715-4

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