Article
Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice.
Nature communications - 1 Aug 2024
Alshoubaki Yasmin K, Nayer Bhavana, Lu Yen-Zhen, Salimova Ekaterina, Lau Sin Nee, Tan Jean L, Amann-Zalcenstein Daniela, Hickey Peter F, Del Monte-Nieto Gonzalo, Vasanthakumar Ajithkumar, Martino Mikaël M
Abstract excerpt
Regulatory T cells (Tregs) are key immune regulators that have shown promise in enhancing cardiac repair post-MI, although the mechanisms remain elusive. Here, we show that rapidly increasing Treg number in the circulation post-MI via systemic administration of exogenous Tregs improves cardiac function in male mice, by limiting cardiomyocyte death and reducing fibrosis. Mechanistically, exogenous Tregs quickly...
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