Article

CHI3L1 drives astrocyte-medicated neuronal injury via GAL3-NLRP3 signaling in ischemic stroke

2026-06-02

Abstract excerpt

<title>Abstract</title> <p>Background: Ischemic stroke lacks effective therapies. Whether chitinase-3-like protein 1 (CHI3L1) is involved in astrocyte-mediated neuronal injury, and its regulatory mechanism in both patient serum and ischemic brain tissue, remain largely unknown. <h4>Methods:</h4> We combined clinical proteomics, mouse tMCAO, in vitro OGD models, and genetic/pharmacological interventions to define...

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Literature Corpus work: dd6d1f5b-5427-51ea-ab23-d190728a72fd
DOI: 10.21203/rs.3.rs-9462748/v1

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