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Chitinase Signature in the Plasticity of Neurodegenerative Diseases

27 Mar 2023

Abstract excerpt

Several reports have pointed out that Chitinases are expressed and secreted by various cell types of central nervous system (CNS), including activated microglia and astrocytes. These cells play a key role in neuroinflammation and in the pathogenesis of many neurodegenerative disorders. Increased levels of Chitinases, in particular Chitotriosidase (CHIT-1) and chitinase-3-like protein 1 (CHI3L1), have been found...

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PMID: 37047273
DOI: 10.3390/ijms24076301

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