Article
Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage.
Aging - 11 Sept 2023
Liang Tianyu, Zhu Zheng, Gong Fangxiao, Yang Xiaobo, Lei Xiaoju, Lu Ling
Abstract excerpt
BACKGROUND: Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and disability rate, and neuroinflammation is involved in secondary brain injury. Galectin-3 (Gal-3) is one of the scaffold proteins of Galectins. Studies have indicated that Gal-3 plays an important role in the physiological and pathological state of the nervous system. Here we focus on the role of Gal-3 in ICH, especially in...
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