Article

Astrocyte-Dependent Neuroinflammation Triggers Hippocampal Neuronal Apoptosis through the TLR4/NF-κB/NLRP3 Axis in Hepatic Encephalopathy

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Cognitive impairment remains a significant neuropsychiatric challenge in hepatic encephalopathy (HE). Characterizing how astrocytes mediate ammonia-driven neuroinflammation may identify therapeutic targets for HE-related cognitive decline. We demonstrate that hippocampal neuronal apoptosis in HE is driven by astrocyte-mediated neuroinflammation through the TLR4/NF-κB/NLRP3 signaling axi...

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Literature Corpus work: c69db0f0-0402-5fca-98b1-690dfb09d3c1
DOI: 10.21203/rs.3.rs-9288348/v1

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Astrocyte-Dependent Neuroinflammation Triggers Hippocampal Neuronal Apoptosis through the TLR4/NF-κB/NLRP3 Axis in Hepatic EncephalopathyDOI 10.21203/rs.3.rs-9288348/v1Read

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