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Article

In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases

1 Jan 2010

Abstract excerpt

BACKGROUND: CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes. METHODS: In the current study CHI3L1 transcription and expression were evaluated in a...

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PMID: 20540736
DOI: 10.1186/1742-2094-7-34

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