Article

Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

2023-04-04

Abstract excerpt

RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a genome-wide appraisal of isoform influence on cell identity in various parts of the brain. Using enhanced long-read single-cell isoform sequencing, we comprehensively analyze RNA isoforms in multiple mouse brain regions, cell subtypes, and developmental timepoints from postnatal day 14 (P14) to adult (P56). For...

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Literature Corpus work: 22c3fc04-85df-5103-902c-8ddcbd912bc8
DOI: 10.1101/2023.04.02.535281

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