Article

Reprogrammed Human Lateral Ganglionic Eminence Precursors Generate Striatal Neurons and Restore Motor Function in a Rat Model of Huntington’s Disease

2024-10-12

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a genetic neurological disorder predominantly characterised by the progressive loss of GABAergic medium spiny neurons in the striatum resulting in motor dysfunction. One potential strategy for the treatment of HD is the development of cell replacement therapies to restore neuronal circuitry and function by the replacement of lost neurons. We propose the generation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fc9b393-6c8e-5d98-87b8-4fe2cea6429a
DOI: 10.1101/2024.10.09.617504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reprogrammed Human Lateral Ganglionic Eminence Precursors Generate Striatal Neurons and Restore Motor Function in a Rat Model of Huntington’s DiseaseDOI 10.1101/2024.10.09.617504Read

Cell Reprogramming to Model Huntington's Disease: A Comprehensive Review.Semantic proximity Read

Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease.Semantic proximity Read

Producing striatal phenotypes for transplantation in Huntington's disease.Semantic proximity Read

Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor cultureSemantic proximity Read

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington’s Disease and Possible Therapeutic AvenuesSemantic proximity Read

Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington’s Disease Mouse StriatumSemantic proximity Read

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS PatientsSemantic proximity Read

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem CellsSemantic proximity Read

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCsSemantic proximity Read

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Semantic proximity Read