Article

CoCUT&Tag maps linked chromatin states at single-molecule, single-cell resolution

2026-04-29

Abstract excerpt

Genomic methods for profiling multiple chromatin features face tradeoffs in specificity, sensitivity, and the ability to measure chromatin co-occupancy in rare cell types and primary tissues. Here, we present CoCUT&Tag, which uses synthetic antigen-peptide repeats paired with nanobodies to enhance Tn5 transposase targeting and enable single-cell measurement of the co-occupancy of two chromatin features on the same...

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Literature Corpus work: dd50ec8a-ca24-5df2-9f5e-2ab9337fe78a
DOI: 10.64898/2026.04.27.721191

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