Article

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington's disease pathology

2019-12-23

Abstract excerpt

<title>Abstract</title> <p>Background: Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elongating the CAG repeats within the Huntingtin gene, resulting in HTT protein misfolding. Although the genetic cause of HD has been established, the specific susceptibil...

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Literature Corpus work: 908d0835-a916-5899-a773-199008e5a502
DOI: 10.21203/rs.2.19435/v1

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