Article

High-resolution detection of copy number alterations in single cells with HiScanner

2024-04-29

Abstract excerpt

Improvements in single-cell whole-genome sequencing (scWGS) assays have enabled detailed characterization of somatic copy number alterations (CNAs) at the single-cell level. Yet, current computational methods are mostly designed for detecting chromosome-scale changes in cancer samples with low sequencing coverage. Here, we introduce HiScanner (High-resolution Single-Cell Allelic copy Number callER), which combines...

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Literature Corpus work: 8b805112-c835-5343-aad9-0643af058d37
DOI: 10.1101/2024.04.26.587806

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