Article

Stem cell derived astrocytes with <i>POLG</i> mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

2020-12-22

Abstract excerpt

The inability to reliably replicate mitochondrial DNA (mtDNA) by mitochondrial DNA polymerase gamma (POLG) leads to a subset of common mitochondrial diseases associated with neuronal death and depletion of neuronal mtDNA. Defining disease mechanisms remains difficult due to the limited access to human tissue. Astrocytes are highly abundant in the brain, playing a crucial role in the support and modulation of neuro...

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Literature Corpus work: 1d430504-5353-5092-940e-77e66afdf007
DOI: 10.1101/2020.12.20.423652

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