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Article

[Pathogenesis and treatment of stroke-like episodes in MELAS].

Rinsho shinkeigaku = Clinical neurology - 1 Nov 2008

Iizuka Takahiro

Abstract excerpt

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a distinct clinical syndrome caused by mutations in mitochondrial DNA. Crucial molecular mechanism includes a lack of taurine modification at the wobble uridine of the mutant tRNA(Leu(UUR)), causing UUG condon-specific translational defect and mitochondrial protein synthesis failure. However, the pathogenesis of...

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Identifiers

PMID: 19198146
DOI: 10.5692/clinicalneurol.48.1006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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