Article

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

2023-12-18

Abstract excerpt

HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results in lipid accumulation in human brains 1 and lipid droplets (LDs) in mouse neurons 2 . In metabolically demanding tissues, TG lipases generate a fatty acid (FA) flux from LDs to fuel mitochondrial ATP production, but neurons are c...

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Literature Corpus work: 46599a09-833e-5c47-914a-d4191f6f128a
DOI: 10.1101/2023.12.18.572201

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