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Article

FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy.

Experimental neurology - 1 Sept 2022

Wu Shusheng, Yin Yuye, Du Longfei

Abstract excerpt

As is the case with neurodegenerative diseases, abnormal accumulation of aggregated proteins in neurons and glial are also known to implicate in the pathogenesis of ischemic stroke. However, the potential role of protein aggregates in brain ischemia remains largely unknown. Fused in Sarcoma (FUS) protein has a vital role in RNA metabolism and regulating cellular homeostasis. FUS pathology has been demonstrated in...

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Source

Identifiers

PMID: 35718207
DOI: 10.1016/j.expneurol.2022.114144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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