Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.

doi:10.1016/j.stemcr.2021.09.013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.

Stem cell reports - 9 Nov 2021

Chandrasekaran Abinaya, Dittlau Katarina Stoklund, Corsi Giulia I, Haukedal Henriette, Doncheva Nadezhda T, Ramakrishna Sarayu, Ambardar Sheetal, Salcedo Claudia, Schmidt Sissel I, Zhang Yu, Cirera Susanna, Pihl Maria, Schmid Benjamin, Nielsen Troels Tolstrup, Nielsen Jørgen E, Kolko Miriam, Kobolák Julianna, Dinnyés András, Hyttel Poul, Palakodeti Dasaradhi, Gorodkin Jan, Muddashetty Ravi S, Meyer Morten, Aldana Blanca I, Freude Kristine K

Abstract excerpt

Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and the endolysosomal pathway in neurons. To dissect the astrocyte-specific impact of mutant CHMP2B expression, we generated astrocytes from human induced pluripotent stem cells (hiPSCs) and confirmed our findings in CHMP2B mutant mice. Our data provide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Endosomal Sorting Complexes Required for Transport

Share to Frontotemporal Dementia

Share to Glycolysis

Share to Homeostasis

Share to Induced Pluripotent Stem Cells

Share to RNA-Seq

Source

Open in PubMed Open full text

Identifiers

PMID: 34678206
DOI: 10.1016/j.stemcr.2021.09.013
PMCID: PMC8581052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.PMID 34678206Read ↗

Astrocytic Reactivity Triggered by defective Mitophagy Activates NF-kB Signaling and Causes Neurotoxicity in Frontotemporal Dementia Type 3Semantic proximity Read ↗

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal deathSemantic proximity Read ↗

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementiaSemantic proximity Read ↗

Glutamate-Glutamine Homeostasis is Perturbed in Neurons and Astrocytes derived from Patient iPSC Models of Frontotemporal DementiaSemantic proximity Read ↗

Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation.Semantic proximity Read ↗

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC-Derived Microglia and Modulates Glial–Neuronal CrosstalkSemantic proximity Read ↗

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's DiseaseSemantic proximity Read ↗

Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.Semantic proximity Read ↗

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B.Semantic proximity Read ↗

LRRK2 I1371V Mutation Drives Astrocytic Glucose Metabolism Failure and Induces Integrated ER-Mitochondria-Lysosome Dysfunction in Parkinson's Disease.Semantic proximity Read ↗

LRRK2 I1371V Impairs Astrocytic Glucose Metabolism and Triggers Multi-Organellar Dysfunction in PDSemantic proximity Read ↗

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.