Article

The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain

2025-03-20

Abstract excerpt

Traumatic brain injury (TBI) is a major risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD), yet the mechanistic link remains unclear. Here, we integrated human patient-derived transcriptomics with a 3D in vitro brain injury model to dissect cell-specific mitochondrial dysfunction as a driver of injury-induced neurodegeneration. Comparative transcriptomic analysis at 6 and 48 hours post-...

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Literature Corpus work: 54ad66a3-f1a2-524b-9e65-b83d7158e552
DOI: 10.1101/2025.03.19.644244

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