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Article

Deletion of chromosome 9p21 noncoding cardiovascular risk interval in mice alters Smad2 signaling and promotes vascular aneurysm.

Circulation. Cardiovascular genetics - 1 Dec 2014

Loinard Céline, Basatemur Gemma, Masters Leanne, Baker Lauren, Harrison James, Figg Nichola, Vilar José, Sage Andrew P, Mallat Ziad

Abstract excerpt

BACKGROUND: Vascular aneurysm is an abnormal local dilatation of an artery that can lead to vessel rupture and sudden death. The only treatment involves surgical or endovascular repair or exclusion. There is currently no approved medical therapy for this condition. Recent data established a strong association between genetic variants in the 9p21 chromosomal region in humans and the presence of cardiovascular...

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Identifiers

PMID: 25176937
DOI: 10.1161/CIRCGENETICS.114.000696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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