Article

Molecular mechanisms of coronary artery disease risk at the <i>PDGFD</i> locus

2023-01-27

Abstract excerpt

Platelet derived growth factor (PDGF) signaling has been extensively studied in the context of vascular disease, but the genetics of this pathway remain to be established. Genome wide association studies (GWAS) for coronary artery disease (CAD) have identified a risk locus at 11q22.3, and we have verified with fine mapping approaches that the regulatory variant rs2019090 and PDGFD represent the functional variant...

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Literature Corpus work: 575674b3-af57-5670-a945-6eb24a089b6f
DOI: 10.1101/2023.01.26.525789

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