Article

Enhanced thermal stability enables human mismatch-specific Thymine-DNA glycosylase to catalyse futile DNA repair

2024-05-23

Abstract excerpt

Human thymine-DNA glycosylase (TDG) excises T mispaired with G in a CpG context to initiate the base excision repair (BER) pathway. TDG is also involved in epigenetic regulation of gene expression by participating in active DNA demethylation. Here we demonstrate that under extended incubation time the full-length TDG (TDG FL ), but not its truncated catalytic domain TDG (TDG cat ) or methyl-binding protein 4 (MB...

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Literature Corpus work: dcee0121-f545-5332-984e-12d09e50c6ac
DOI: 10.1101/2024.05.21.595234

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