Article
Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2017
Nakamura Tomohumi, Murakami Kouichi, Tada Haruto, Uehara Yoshihiko, Nogami Jumpei, Maehara Kazumitsu, Ohkawa Yasuyuki, Saitoh Hisato, Nishitani Hideo, Ono Tetsuya, Nishi Ryotaro, Yokoi Masayuki, Sakai Wataru, Sugasawa Kaoru
Abstract excerpt
Thymine DNA glycosylase (TDG) is a base excision repair (BER) enzyme, which is implicated in correction of deamination-induced DNA mismatches, the DNA demethylation process and regulation of gene expression. Because of these pivotal roles associated, it is crucial to elucidate how the TDG functions are appropriately regulated in vivo. Here, we present evidence that the TDG protein undergoes degradation upon...
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